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IMM2510 is a novel, bispecific antibody consisting of an anti-PD-L1 antibody fused to a vascular endothelial growth factor (VEGF) receptor “trap” which binds VEGF. IMM2510 is differentiated from other PD(L)1xVEGF antibodies by its ability to bind multiple VEGF receptor ligm88 casino reviews beyond VEGF-A, a smaller molecular weight allowing for potentially better tumor penetration, m88 casino review enhanced antibody-dependent cellular cytotoxicity (ADCC) designed to improve the killing of tumors. IMM2510 has completed a dose-escalation clinical trial for advanced solid tumors m88 casino review this demonstrated multiple responses including in patients with squamous non-small cell lung cancer (NSCLC) who previously failed PD-1 inhibitors.
IMM27M is a next-generation anti-CTLA-4 antibody with enhanced ADCC activity, which is designed to promote intratumoral regulatory T cell depletion to enhance the efficacy m88 casino review reduce the toxicity associated with first-generation anti-CTLA-4 antibodies. IMM27M has completed a dose-escalation clinical trial demonstrating anti-tumor activity in patients with advanced solid tumors m88 casino review in July 2024, entered combination studies with IMM2510 in China.
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